Isolated Limb Perfusion and External Beam Radiotherapy for Soft Tissue Sarcomas of the Extremity: Long-Term Effects on Normal Tissue According to the LENT-SOMA Scoring System
Identifieur interne : 006A65 ( Main/Exploration ); précédent : 006A64; suivant : 006A66Isolated Limb Perfusion and External Beam Radiotherapy for Soft Tissue Sarcomas of the Extremity: Long-Term Effects on Normal Tissue According to the LENT-SOMA Scoring System
Auteurs : Miriam L. Hoven-Gondrie ; Katja M. J. Thijssens ; Jan H. B. Geertzen ; Elisabeth Pras ; Robert J. Van Ginkel ; Harald J. HoekstraSource :
- Annals of Surgical Oncology [ 1068-9265 ] ; 2008.
Abstract
With the combined treatment procedure of isolated limb perfusion (ILP), delayed surgical resection and external beam radiotherapy (EBRT) for locally advanced soft tissue sarcomas (STS) of the extremities, limb salvage rates of more than 80% can be achieved. However, long-term damage to the healthy surrounding tissue cannot be prevented. We studied the late effects on the normal tissue using the LENT-SOMA scoring system.
A total of 32 patients—median age 47 (range 14–71) years—were treated for a locally advanced STS with ILP, surgical resection and often adjuvant 60–70 Gy EBRT. After a median follow-up of 88 (range 17–159) months, the patients were scored, using the LENT-SOMA scales, for the following late tissue damage: muscle/soft tissue, peripheral nerves, skin/subcutaneous tissue and vessels.
According to the individual SOM parameters of the LENT-SOMA scales, 20 patients (63%) scored grade-3 toxicity on one or more separate items, reflecting severe symptoms with a negative impact on daily activities. Of these patients, 3 (9%) even scored grade-4 toxicity on some of the parameters, denoting irreversible functional damage necessitating major therapeutic intervention.
In evaluating long-term morbidity after a combined treatment procedure for STS of the extremity, using modified LENT-SOMA scores, two-thirds of patients were found to have experienced serious late toxic effects.
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DOI: 10.1245/s10434-008-9850-0
PubMed: 18330652
PubMed Central: 2277454
Affiliations:
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Box 30.001, Groningen, 9700 RB The Netherlands</nlm:aff><wicri:noCountry code="subfield">9700 RB The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Geertzen, Jan H B" sort="Geertzen, Jan H B" uniqKey="Geertzen J" first="Jan H. B." last="Geertzen">Jan H. B. Geertzen</name><affiliation><nlm:aff id="Aff2">Department of Rehabilitation, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen, 9700 RB The Netherlands</nlm:aff><wicri:noCountry code="subfield">9700 RB The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Pras, Elisabeth" sort="Pras, Elisabeth" uniqKey="Pras E" first="Elisabeth" last="Pras">Elisabeth Pras</name><affiliation><nlm:aff id="Aff3">Department of Radiotherapy, University Medical Center Groningen, University of Groningen, P.O. 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Hoven-Gondrie</name><affiliation><nlm:aff id="Aff1">Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen, 9700 RB The Netherlands</nlm:aff><wicri:noCountry code="subfield">9700 RB The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Thijssens, Katja M J" sort="Thijssens, Katja M J" uniqKey="Thijssens K" first="Katja M. J." last="Thijssens">Katja M. J. Thijssens</name><affiliation><nlm:aff id="Aff1">Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen, 9700 RB The Netherlands</nlm:aff><wicri:noCountry code="subfield">9700 RB The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Geertzen, Jan H B" sort="Geertzen, Jan H B" uniqKey="Geertzen J" first="Jan H. B." last="Geertzen">Jan H. B. Geertzen</name><affiliation><nlm:aff id="Aff2">Department of Rehabilitation, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen, 9700 RB The Netherlands</nlm:aff><wicri:noCountry code="subfield">9700 RB The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Pras, Elisabeth" sort="Pras, Elisabeth" uniqKey="Pras E" first="Elisabeth" last="Pras">Elisabeth Pras</name><affiliation><nlm:aff id="Aff3">Department of Radiotherapy, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen, 9700 RB The Netherlands</nlm:aff><wicri:noCountry code="subfield">9700 RB The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Van Ginkel, Robert J" sort="Van Ginkel, Robert J" uniqKey="Van Ginkel R" first="Robert J." last="Van Ginkel">Robert J. Van Ginkel</name><affiliation><nlm:aff id="Aff1">Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen, 9700 RB The Netherlands</nlm:aff><wicri:noCountry code="subfield">9700 RB The Netherlands</wicri:noCountry></affiliation></author><author><name sortKey="Hoekstra, Harald J" sort="Hoekstra, Harald J" uniqKey="Hoekstra H" first="Harald J." last="Hoekstra">Harald J. Hoekstra</name><affiliation><nlm:aff id="Aff1">Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen, 9700 RB The Netherlands</nlm:aff><wicri:noCountry code="subfield">9700 RB The Netherlands</wicri:noCountry></affiliation></author></analytic><series><title level="j">Annals of Surgical Oncology</title><idno type="ISSN">1068-9265</idno><idno type="eISSN">1534-4681</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>With the combined treatment procedure of isolated limb perfusion (ILP), delayed surgical resection and external beam radiotherapy (EBRT) for locally advanced soft tissue sarcomas (STS) of the extremities, limb salvage rates of more than 80% can be achieved. However, long-term damage to the healthy surrounding tissue cannot be prevented. We studied the late effects on the normal tissue using the LENT-SOMA scoring system.</p></sec><sec><title>Patients and Methods</title><p>A total of 32 patients—median age 47 (range 14–71) years—were treated for a locally advanced STS with ILP, surgical resection and often adjuvant 60–70 Gy EBRT. After a median follow-up of 88 (range 17–159) months, the patients were scored, using the LENT-SOMA scales, for the following late tissue damage: muscle/soft tissue, peripheral nerves, skin/subcutaneous tissue and vessels.</p></sec><sec><title>Results</title><p>According to the individual SOM parameters of the LENT-SOMA scales, 20 patients (63%) scored grade-3 toxicity on one or more separate items, reflecting severe symptoms with a negative impact on daily activities. Of these patients, 3 (9%) even scored grade-4 toxicity on some of the parameters, denoting irreversible functional damage necessitating major therapeutic intervention.</p></sec><sec><title>Conclusions</title><p>In evaluating long-term morbidity after a combined treatment procedure for STS of the extremity, using modified LENT-SOMA scores, two-thirds of patients were found to have experienced serious late toxic effects.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Geertzen, Jan H B" sort="Geertzen, Jan H B" uniqKey="Geertzen J" first="Jan H. B." last="Geertzen">Jan H. B. Geertzen</name><name sortKey="Hoekstra, Harald J" sort="Hoekstra, Harald J" uniqKey="Hoekstra H" first="Harald J." last="Hoekstra">Harald J. Hoekstra</name><name sortKey="Hoven Gondrie, Miriam L" sort="Hoven Gondrie, Miriam L" uniqKey="Hoven Gondrie M" first="Miriam L." last="Hoven-Gondrie">Miriam L. Hoven-Gondrie</name><name sortKey="Pras, Elisabeth" sort="Pras, Elisabeth" uniqKey="Pras E" first="Elisabeth" last="Pras">Elisabeth Pras</name><name sortKey="Thijssens, Katja M J" sort="Thijssens, Katja M J" uniqKey="Thijssens K" first="Katja M. J." last="Thijssens">Katja M. J. Thijssens</name><name sortKey="Van Ginkel, Robert J" sort="Van Ginkel, Robert J" uniqKey="Van Ginkel R" first="Robert J." last="Van Ginkel">Robert J. Van Ginkel</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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